Ipamorelin Vs Sermorelin: Heres What You Need To Know Ipamorelin Vs Sermorelin: Heres What You Need To Know Ipamorelin vs. Sermorelin: Here’s What You Need to Know When it comes to boosting growth hormone (GH) levels naturally, two peptides often steal the spotlight—Ipamorelin and Sermorelin. Though both aim to stimulate the pituitary gland and increase GH production, they differ in structure, duration of action, and clinical use. Understanding these nuances helps you choose the right option for your health goals. What are HGH peptides and how do they work? Human Growth Hormone (HGH) peptides are small chains of amino acids that mimic or stimulate the body’s own hormones. They target receptors on pituitary cells, prompting the release of growth hormone into circulation. Unlike direct GH injections, peptide therapy leverages the body’s natural regulatory mechanisms, often leading to more balanced and sustained hormone levels. How does Ipamorelin vs. Sermorelin work to stimulate HGH? Sermorelin is a synthetic version of Growth Hormone Releasing Hormone (GHRH). It binds to GHRH receptors on pituitary cells, causing a cascade that releases growth hormone. Its effect lasts for about 2–3 hours before the peptide is metabolized. Ipamorelin, on the other hand, is a ghrelin receptor agonist. By mimicking the hunger hormone ghrelin’s action on its receptors, Ipamorelin stimulates GH release with minimal influence on cortisol or prolactin levels. Its half-life is shorter—roughly 30–45 minutes—but it can be administered more frequently for steadier peaks. What are the benefits of Peptide Therapy?